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C.I. Oxidation Base 26

Catechol

CAS: 120-80-9

Molecular Formula: C6H6O2

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C.I. Oxidation Base 26 - Names and Identifiers

Name Catechol
Synonyms Catechol
C.I. 76500
Pyrocatechol
ai3-03995[qr]
1,2-Benzenediol
2-Hydroxyphenol
benzene-1,2-diol
2-hydroxyphenol[qr]
1,2-benzenediol[qr]
Benzene, o-dihydroxy-
C.I. Oxidation Base 26
benzene,1,2-dihydroxy-
1,2-dihydroxybenzene[qr]
1,2-Benzenediol (pyrocatechol)
CAS 120-80-9
EINECS 204-427-5
InChI InChI=1/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H

C.I. Oxidation Base 26 - Physico-chemical Properties

Molecular FormulaC6H6O2
Molar Mass110.11
Density1,371 g/cm3
Melting Point100-103 °C (lit.)
Boling Point245 °C (lit.)
Flash Point279°F
Water Solubility430 g/L (20 ºC)
Solubility 430g/l
Vapor Presure1 mm Hg ( 75 °C)
Vapor Density3.8 (vs air)
AppearanceCrystalline Flakes
Colorwhite to faintly beige
Exposure LimitTLV-TWA 5 ppm (～22 mg/m3) (ACGIH). .
Merck14,7999
BRN471401
pKa9.85(at 20℃)
PH6 (100g/l, H2O, 20℃)
Storage ConditionStore below +30°C.
StabilityStable. Substances to be avoided include acid chlorides, acid anhydrides, bases, oxidizing agents, nitric acid. Light sensitive; may discolour on exposure to air. Combustible.
SensitiveAir & Light Sensitive
Explosive Limit1.97%(V)
Refractive Index1.6120 (estimate)
Physical and Chemical PropertiesCharacter: colorless crystals. Discoloration in air and light. Its solution in the air into a tan, see light or open air discoloration, can sublimate.
soluble in 2.3 times water, soluble in ethanol, ether, benzene, chloroform, soluble in pyridine and caustic liquid.
UseIs an important chemical intermediate, can be used as rubber hardening agent, electroplating additives, skin antiseptic, hair dye, photo developer, color photo antioxidant

C.I. Oxidation Base 26 - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR21/22 - Harmful in contact with skin and if swallowed.
R36/38 - Irritating to eyes and skin.
R68 - Possible risk of irreversible effects
R43 - May cause sensitization by skin contact
Safety DescriptionS22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37 - Wear suitable gloves.
S39 - Wear eye / face protection.
UN IDsUN 2811 6.1/PG 3
WGK Germany2
RTECSUX1050000
TSCAYes
HS Code2907 29 00
Hazard Class6.1
Packing GroupIII
ToxicityLD50 in mice (mg/kg): 260 orally; 190 i.p. (Lehman)

C.I. Oxidation Base 26 - Upstream Downstream Industry

Downstream Products3-Ethoxy-4-hydroxybenzaldehyde

C.I. Oxidation Base 26 - Nature

Open Data Verified Data

colorless crystals. Discoloration in air and light. The solution turned tan in air. Flammable. The relative density was 1. 37. The melting point of 1 05 deg C (104~1 05 deg C). Boiling point 246 °c (look kPa). Flash point (Open Cup) 127 °c. Can sublimate. Ignition point (in a closed kettle) 127 °c. Soluble in 2.3 times water, soluble in ethanol, ether, benzene, chloroform, soluble in pyridine and caustic liquid.

Last Update：2024-01-02 23:10:35

C.I. Oxidation Base 26 - Preparation Method

Open Data Verified Data

prepared by hydrolysis of O-chlorophenol in alkaline medium.

Last Update：2022-01-01 10:41:49

C.I. Oxidation Base 26 - Use

Open Data Verified Data

An important pharmaceutical intermediate for the preparation of berberine (berberine) and isoproterenol. Can also be prepared spices (piperonal), dyes, photosensitive materials, electroplating materials, special inks, antioxidants, light stabilizers, preservatives and accelerators.

Last Update：2022-01-01 10:41:49

C.I. Oxidation Base 26 - Safety

Open Data Verified Data
  • toxic. It can stimulate the central nervous system and respiratory system. Rat oral LD50 3890mg/kg. Different from resorcinol and hydroquinone. This product is not toxic. Inhalation of a small amount of this product, can be formed in the body of Organic sulfate and detoxification, with the urine out of the body. Production equipment should be closed, and the operator should wear protective equipment.
  • the use of 25 ~ 180kg iron drum packaging. Storage and Transportation shall be in accordance with the provisions for general combustible chemicals.
Last Update：2022-01-01 10:41:50

C.I. Oxidation Base 26 - Reference Information

LogP0.93
(IARC) carcinogen classification 2B (vol. 15, Sup 7, 71) 1999
NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
use is an important chemical intermediate, which can be used to make rubber hardener, electroplating additive, skin antiseptic fungicide, hair dye, photographic developer, etc.
used as analytical reagent
catechol is an intermediate of fungicide ethamarb, insecticide propoxel and carbofuran.
As an important pharmaceutical intermediate, it is used to make berberine and isoproterenol. It can also be used to produce 4-tert-butylcatechol as a polymerization inhibitor for styrene, butadiene and vinyl chloride. Or used in the manufacture of antioxidants, developers, fungicides, rubber additives, electroplating additives, special inks, light stabilizers, dyes, spices, etc.
is an important pharmaceutical intermediate, which can be used to make cough, eugenol, berberine and isoprenaline.
It is an important chemical intermediate, which can be used as rubber hardener, electroplating additive, skin antiseptic, hair dye, photographic developer, color antioxidant, etc.
It is used for photography, dyes, antioxidants, light stabilizers, and is an important pharmaceutical intermediate
Color reaction or colorimetric analysis to determine titanium, molybdenum, tungsten, vanadium, iron and cerium.
Production method Catechol mostly exists in nature in the form of derivatives. For example, o-methoxyphenol and 2-methoxy-4-methylphenol are important for beech creosote oils. Catechol was first obtained by distilling protocatechuic acid or distilling catechu extract: it was later discovered that catechol can also be obtained by dry distillation of certain plants or alkali melting of certain resins. In industry, in the past, it was generally extracted from tar by low-temperature dry distillation of coal. There are many processes for the synthesis of catechol. (1) Using phenol as raw material, it is obtained by chlorination of chlorine, hydrolysis of copper sulfate and sodium hydroxide, and acidification of hydrochloric acid. (2) Direct oxidation by benzene or phenol and hydrogen peroxide. The direct oxidation of phenol with hydrogen peroxide to produce catechol includes Ube Kechang Company of Japan and Rhone-Planck Company of France. (3) It is prepared by pressure hydrolysis of o-chlorophenol in alkaline medium.
its preparation methods are as follows: 2,4-disulfophenol alkali fusion hydrolysis method; o-chlorophenol hydrolysis method; phenol direct oxidation method; phenol oxidation method; o-hydroxycyclohexanone dehydroaromatization method. Among them, (1) and (2) processes are complicated, and the three wastes are polluted more, which are gradually replaced by new processes, while methods (4) and methods (5) are undergoing industrial tests abroad. The direct oxidation of phenol uses hydrogen peroxide as the oxidant, and the hydroxylation reaction occurs directly at the o-and para-positions of phenol in the presence of a catalyst. After entering the 2070s, this method has achieved great success. France's Rhône-Planck Company built a set of 10800t/a catechol and 7200t/a hydroquinone industrial plant in 1973, and Japan's Yuduxing Industrial Company also built a set of 600t/a catechol plant. Direct oxidation has become the simplest method to produce catechol. Methyl isobutyl ketone is used as extractant for extraction and separation of o-hydroquinone and unreacted phenol. The process is directly oxidized by phenol and hydrogen peroxide. This method has been industrialized abroad and in China in recent years. Phenol and methyl ethyl ketone, 60% H2O2, activated clay VH and 85% H3PO4 were added into the reactor, stirred at 100 ℃ for 30min, and phenol was converted into catechol and hydroquinone.
category pesticide
toxicity classification highly toxic
acute toxicity oral-rat LD50: 260 mg/kg; Oral-mouse LD50: 260 mg/kg
Explosive hazard characteristics Severe reaction with oxidant
flammability hazard characteristics when heated, open flames are combustible; burning produces stimulating smoke
storage and transportation characteristics warehouse ventilation and low temperature drying; Store separately from oxidants and food additives
fire extinguishing agent mist water, carbon dioxide, sand
occupational standard TWA 20 mg/m3
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 15:16:47
C.I. Oxidation Base 26
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Jinan Huifengda Chemical Co.,Ltd.
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Product Name: Catechol Request for quotation
CAS: 120-80-9
Tel: +86-531-88872378
Email: jnhuifengda@163.com
Mobile: +86-013156148719
QQ: 344046944 Click to send a QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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Product Name: Norepinephrine Impurity 11 Visit Supplier Webpage Request for quotation
CAS: 120-80-9
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Email: 2853786052@qq.com
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JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
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Tel: +86-17551318830
Email: r@reformchem.com
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Catechol Request for quotation
CAS: 120-80-9
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Catechol Request for quotation
CAS: 120-80-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Catechol Request for quotation
CAS: 120-80-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: Pyrocatechol Request for quotation
CAS: 120-80-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
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C.I. Oxidation Base 26
Downstream Products for C.I. Oxidation Base 26
3-Ethoxy-4-hydroxybenzaldehyde
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